Seyed Reza Rahimi Moghaddam; Alireza Elmieh; Mohammad Reza Fadaei
Abstract
Objective: Neutrophils contain myeloperoxidase enzyme, which is involved in many cellular processes by producing oxidants and catalyzing hypochlorous acid. On the other hand, from middle age, physiological protection against oxidative stress starts to decrease. Therefore, the main purpose of this study ...
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Objective: Neutrophils contain myeloperoxidase enzyme, which is involved in many cellular processes by producing oxidants and catalyzing hypochlorous acid. On the other hand, from middle age, physiological protection against oxidative stress starts to decrease. Therefore, the main purpose of this study was to determine myeloperoxidase and total oxidative status changes in healthy trained middle-aged men participating in regular recreational exercise training and untrained subjects.Methodology: 20 trained (age 53.85±2.94, BMI 25.47±1.6, VO2max 42.38±2.8) and 17 untrained (age 54.17±2.83, BMI 27.83±1.12, VO2max 31.86±1.67) subjects participated in the study. Subjects performed a modified Bruce treadmill test as a model of progressive exercise training. Blood samples were taken before (T0), immediately after (T1) and one hour after the end of the test (T2).Results: There was no significant changes in pretest myeloperoxidase level in both groups, but these values were significantly changed in untrained group compared to the trained group at T1 and T2. Total oxidant status levels in both groups increased significantly after completing the test compared to the pretest. Conclusion: Regular participation in recreational exercise training can reduce the level of myeloperoxidase and total oxidative capacity of healthy middle-aged men, and may be a proper way to have a healthy lifestyle along with reduced immune system and oxidative stress markers caused by aging in middle-aged men.
